P86 - Magnesium sulphate in the management of severe asthma and atelectasis
نویسنده
چکیده
Introduction Magnesium sulphate (MS), causes bronchodilation by inhibiting bronchial smooth muscle contraction, interferes with parasympathetic stimulation, and prevents acetylcholine release to axon terminals [1]. It reduces inflammation by inhibiting mast cell degranulation and reduces thromboxane, histamine and leukotrienes [2]. Some pediatric studies suggest that MS, b-2-agonists and steroids are beneficial in acute moderate/severe asthma by reducing hospitalization and absolute risk [3].
منابع مشابه
Review of the role of magnesium sulphate in the management of asthma patient at A&E setting
Controversial views exist with regards to the use of intravenous magnesium sulphate in patient with severe asthmatic attack. The benefit of intravenous magnesium sulphate may be masked by the pooling of patients with different pathophysiology. The subsets of patients with severe asthmatic attack who have not responded to nebulised bronchodilator therapy and intravenous steroid therapy may benef...
متن کاملMagnesium sulphate in the treatment of acute asthma: evaluation of current practice in adult emergency departments.
BACKGROUND A recent meta-analysis showed that intravenous and nebulised magnesium sulphate have similar levels of evidence to support their use in the treatment of acute asthma in adults. This consisted of weak evidence of effect on respiratory function and hospital admissions, with wide confidence intervals ranging from no effect to significant positive effects. Current BTS/SIGN guidelines sug...
متن کاملEffectiveness of magnesium sulfate as initial treatment of acute severe asthma in children, conducted in a tertiary-level university hospital: a randomized, controlled trial.
INTRODUCTION Magnesium sulfate is a calcium antagonist that inhibits bronchial smooth muscle contraction promoting bronchodilation. It is used for the management of acute severe asthma in children; however most of the studies have been performed in adults. OBJECTIVE To evaluate the effectiveness of intravenous magnesium sulfate for the treatment of pediatric patients with acute severe asthma ...
متن کاملUse of magnesium in moderating tachycardia in acute severe asthma in pregnancy.
1 Sellers WFS. Inhaled and intravenous treatment in acute severe and life-threatening asthma. Br J Anaesth 2013; 110: 183–90 2 Patel A, Harrison E, Durward A, et al. Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment. Br J Anaesth 2000; 84: 505–7 3 Durward A, Forte V, Shemie SD. Resolution of mucus plugging and atelectasis aft...
متن کاملA meta-analysis on intravenous magnesium sulphate for treating acute asthma.
AIM To evaluate the effectiveness of intravenous magnesium sulphate in the treatment of acute asthmatic attacks in children by meta-analysis. METHODS A systematic and comprehensive search of the literature was performed to identify controlled clinical trials of magnesium sulphate in paediatric acute asthma which evaluated outcomes of hospitalisation or short term pulmonary function tests or s...
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